Raaz K Maheshwari*1, Lalit Mohan2, Bhavana Upadhyay3
1Department of Chemistry, SBRM Govt PG College, Nagaur, Rajasthan, India
2Department of Zoology, Dayalbagh Educational Institute, Agra, UP, India
3Department of Zoology, Agra PG College, Agra, UP, India
Garcinia cambogia has been the subject of extensive phytochemical and physiologcal studies because of its derivatives used in human body metabolism. The major part of research activities concentrate on weight reduction and fat metabolism. Garcinia cambogia fruit’s identified as a natural source of HCA which is chemically very similar to citric acid found in oranges and other citrus fruits. The herb is known to lower lipid levels and assists in overall weight loss. The rind of the Garcinia fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, healthy appetite levels and optimum body weight Rather than the traditional uses and applications, recent studies revealed the pharmacological applications of HCA. It has been reported that HCA affects Lipid metabolism. Hydroxy citric acid has a respectable history of scientific investigation. HCA is found to be the first natural weight loss, compound without adversely affecting the CNS. This shows that Garcinia is not a stimulant, that it will not interfere with sleep and it will not cause changes in heart rate or blood pressure. Hence HCA is known as a safe fat fighting agent. Herbal supplement of HCA decreases adipose tissue weight after ingestion for few weeks. Several clinical studies have been undertaken to assess the efficacy of Garcinia Cambogia. At the moment the research is a little patchy and generally the medical community recommends more testing.
Keywords: OTCS; HCA; LDL; CNS, Stimulation; Thermogenesis; Lactone; Serotonin ATPC; Citrate lyase; Fatty acid synthesis; Lipogenesis; Appetite; Antiobesity