Vennela K.G*1, Ramesh Reddy K1, Uma Sankar K1, Jayachandra Reddy P2 1Department of Pharmaceutics, Krishna Teja Pharmacy College, Chadalwada Nagar, Reniguntla Road, Tirupathi-517 506, Chittoor (dist), A.P., India 2Department of Pharmaceutical Analysis, Krishna Teja pharmacy College, Chadalwada Nagar, Reniguntla Road, Tirupathi-517 506, Chittoor (dist), A.P., India.
The objective of this study was to design Glimepiride Immediate Release tablets. It is mainly used for the treatment of type 2 diabetics, sulphonylureas plays important role as therapeutic as well as maintenance therapy. Glimepiride is Anti diabetic drug. It is used for type 2 diabetic disorders, very low solubility in aqueous media & oral bioavailability is 100%.its half life is 5-8 hrs & very low clearance 48 ml/min. Tablets were prepared by wet granulation technique using different polymers such as Lactose Monohydrate, Starch, Magnesium Stearate, Povidone K 30 as release rate retardant , Colloidal silicon dioxide, Sodium starch glycolate, Cross carmelose sodium, Crossprovidone, Povidone k-90, Avicel PH 102, as release rate retardant and tablets were evaluated for hardness, friability, weight variation, thickness and drug content uniformity. In vitro release studies were performed using USP type II apparatus (Basket method). In vitro release studies revealed that the release rate decreased with increase of polymer loading. The Drug release was analyzed using zero-order, first order and Higuchi and Korsmeyer-Peppas equations to explore and explain the mechanism of drug release from the Immediate Release tablets. Mathematical analysis of the release kinetics indicated that release from the immediate tablets followed diffusion. So the Immediate tablets could be a potential dosage form for delivering Glimepiride .
Keywords: Glimepiride, Immediate Release tablets, Hydrophilic polymers, Wet granulation.