Saturday , 8 May 2021

Formulation and Screening of Topical Herbal Liposomal Gel for Analgesic and Anti-Inflammatory Activity

Sneha Thakur*1, Rimsha Fatima1, Shaistha Samreen1, Tasneem Fatima1, Tahniyat Fatima1, Mamidi Upendar2
1Bojjam Narasimhulu Pharmacy College, Sayeedabad, Hyderabad, Telangana-500059.
2KP Labs, kothapet, Hyderabad-500035

Liposomal formulations have been successfully used in the treatment of a number of dermatological diseases. Various synthetic as well as herbal drugs are incorporated into liposome to improve its efficacy. Incorporation of herbal extract into liposome reduces side effects which are associated with the synthetic ones. Adhesiveness, stability and release of incorporated herbal extracts are the main features that influence the applicability of hydrogels for topical treatment, including the wound healing process. Adjustment of the textural properties of hydrogel should be conducted routineosly. The texture analyzer measurements can provide deeper insight on gel adhesivness. The gel properties are dependent on the polymer concentration and the pH. Carbopol hydrogels can take up to 15% (w/w) of liposomal dispersions, however, the stability of the liposomal gels need to be evaluated as well. Carbopol hydrogels can be used as advanced drug delivery systems. And the optimized formulation was selected by the basis of invitro drug release of the all the formulations.

Keywords: liposomal gel, hydrogel, liposomesm, polyherbal.

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