Thursday , 24 September 2020

Formulation and In-vitro Evaluation of Matrix Diffusion Controlled Release Tablets of Itopride as Model Drug

P. Bhavana1, Dr. K. Abbulu2*, Sowjanyabattu3
1CMR College of pharmacy, Kandlakoya, Medchal, Hyderabad, 501401, Telangana, India.
2Professor & Principal, Dept of Pharmaceutics, CMR College of pharmacy, Kandlakoya, Medchal, Hyderabad, 501401, Telangana, India.
3Associate Professor & Head, Dept of Pharmaceutics, CMR College of pharmacy, Kandlakoya, Medchal, Hyderabad, 501401, Telangana, India.

A B S T R A C T
In the present work, an attempt has been made to develop controlled release tablets of Itopride by selecting karaya gum, HPMC K 15 M, locust bean gum as retarding polymers. All the formulations were prepared by direct compression method using 9mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F5 formulation prepared with 50mg karaya gum showed maximum % drug release i.e., 98.05 % in 12 hours hence it is considered as optimized formulation. Whereas the formulations containing xanthan gum showed more retarding with increasing concentration of polymer. The formulations with HPMC K 15 M, locust bean gum were unable to produce the desired rug release pattern.
Keywords: Itopride, Karaya gum, HPMC K 15 M, Locust bean gum, controlled release

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