Wednesday , 21 October 2020

Formulation and In-Vitro Evaluation of Fast Dissolving Oral Film of Sumatriptane by Using Natural Polymers

Pavithra1, P. Thulasi2, E. Bala Krishna3, B. Jaya Subba Reddy4, S. Durga5, K. Sunil kumar6
1,2,3,4,5Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.
6Associate Professor, Department of Pharmaceutics, Sun Institute of Pharmaceutical Education
and Research, Kakupalli, Nellore, Andhra Pradesh, India.

A B S T R A C T
The objective of the present investigation was to formulate and evaluate fast dissolving tablets of Sumatriptane by solvent casting method. Xanthane gum, sodium alginate and guar gum were used as polymers for the preparation of Sumatriptane oral dissolving films. Sumatriptane selectively binds to and activates serotonin 5- HT1 Dreceptors in the CNS, used to treatment of migraine headache. Around twelve formulations of Sumatriptane were developed as fast dissolving films using various Excipients which were found to be compatible using FTIR of films. Sumatriptane films were evaluated for quality control tests such as thickness, weight variation, folding endurance, SEM, surface pH, disintegration time, in-vitro dissolution, drug content, and stability study. The in-vitro drug study of F2 was found to give the highest % drug release then other formulations. Optimized formulation F2 made found to be stable at accelerated stability condition
Keywords: Sumatriptane, Solvent casting method, Xanthane gum, Formulation, Polymer

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