Mallikarjun Vasam*1, Dr. S.N. Sri Harsha1, P. Hyma2, D. Yashwanth Kumar2
1Pacific University, Udaipur, Rajasthan, India.
2SARC (Scientific and Applied Research Center), Hyderabad, Telangana, India
A B S T R A C T
The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water-soluble drug, cefdinir, using Copolymers synthesized from acrylic and methacrylic acid esters (Eudragit RS 100 and RL 100) as the retardant material. Microspheres were prepared by solvent evaporation method using an acetone / liquid paraffin system. Magnesium stearate was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their micromeritic properties and drug loading, as well by Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy. The in vitro release studies were performed in pH 6.8, phosphate buffer. The prepared microspheres were white, free flowing and spherical in shape. The drug-loaded microspheres showed 67-91% of entrapment and release was extended up to 6 to 8 h. The infrared spectra showed stable character of cefdinir in the drug-loaded microspheres and revealed the absence of drug polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The best-fit release kinetics was achieved with Higuchi plot followed by zero order and First order. The release of cefdinir was influenced by the drug to polymer ratio and particle size & was found to be diffusion controlled.
Keywords: Cefdinir, Eudragit, microspheres, controlled release, polymethacrylate.