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Veerapuram Kumar Reddy*1, Ramesh Y2, Parkavi J1, BalaKrishnan M1
1Seshachala College of Pharmacy, Tirupathi – Chennai High way, Puttur-517 583, Chittoor, Andhra Pradesh, India
2Ratnam Institute of pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore, Pin- 524346, Andhra Pradesh, India
A B S T R A C T
The Mucoadhesive films are also known as patches, containing dispersed or dissolved drug with plasticizers, polymers, etc are intended to deliver a therapeutically effective amount of drug across the skin. The aim of the present study was to prepare and evaluate Mucoadhesive films containing Meloxicam by using to different formulations codes like Film I like Drug, HPMC (15cps), glycerin, Ethanol. Film II shows Drug, HPMC (15 cps), Eudragits, tween 80, Acetone, Ethanol. Transdermal patches of Meloxicam with Film I and II by varying the blend ratios were prepared by solvent casting method. The films were tested for their potential to cause skin irritation in few human beings. Thin, flexible, smooth Patches of Meloxicam were obtained with various Films I and II blends. The FT-IR confirmed no interaction between the drug and polymers. Thickness, Tensile strength, Swelling studies, Weight variations, Content uniformity, In Vitro Release Studies of Meloxicam Films in Sorensen’s Phosphate Buffer (pH 6.2) were found to be uniform and reproducible. It could be concluded that the polymeric matrix-type transdermal patches of biopolymer based transdermal Patches are potential vehicles for improved transdermal delivery of Meloxicam.
Keywords: Meloxicam, HPMC (15 cps), Eudragits, Mucoadhesive films.
