M. Lavanya, B. Rohith Pavan, C. Jomitha Johny, P. Mounika, Naresh Gorantla*
Department of Pharmaceutics, Balaji College of pharmacy, Ananthapuramu, Andhra Pradesh, India.
A B S T R A C T
Periodontitis disease is a group of illness located in the gums and dental support structures and produced by certain bacteria i.e. Actinobacillus. Studies have suggested that Punica granatum is used for the treatment of microbial infections especially in dental diseases. Punica granatum is an ancient, unique plant belongs to family lythraceae consists chemical constituents like ellagic acid, ellagitannins, punicic acid, flavonoids, anthocyanins, anthocyanidines and estrogenic flavonols & flavonols. The rind of pomegranate consists of flavonoids and the extract was prepared by cold maceration process and was used as active ingredient to prepare medicated gels for the treatment of Periodontitis. 10 formulations i.e. F1 to F10 were prepared by incorporating 1 % extract and with different gelling agents at different concentrations like Sodium alginate, Guar gum, Sodium carboxy methyl cellulose, Methyl cellulose and Hydroxy propyl methyl cellulose. The prepared gels were evaluated for parameters like Appearance, spreadability, consistency, Ph & stability studies. The prepared gels showed good physical appearance and good stability condition hence we conclude our work that gels can be prepared successfully and used for the treatment of periodontitis and further optimization studies are to be done for the commercial success of the medicated gels of pomegranate rind extract.
Keywords: cardiovascular, diseases, Angiotensin II, olmesartan, telmisartan, hypertension.