Dr. T. Satyanarayana*, K. Mounika, D. Nirmala Kumari, B. Saraswathi, K. Lalitha
Mother Theresa Pharmacy College, Sathupally, Khammam, Telangana, India
A B S T R A C T
The objective of the present study is formulation and evaluation of Terbutaline sulfate microbeads to improve drug oral bioavailability. Terbutaline sulfate microbeads were prepared by ionotropic external gelatation technique using sodium alginate, locust bean gum in different ratios, various formulations were prepared with these polymers. The Terbutaline sulfate microbeads were characterized with respect to IR, DSC, XRD, swelling studies, angle of repose, bulk density, tapped density, Carr’s index Hausner’s ratio, and stability studies and all the results indicated that the microbeads were having good flow nature. By the invitro dissolution studies it was concluded that the formulation (F4) was showing better result of 98.97% drug release. FTIR and DSC studies showed that there is no incompatability between the drug and polymers. The data was subjected to Zero order, first order, Higuchi, Korsmeyer and Peppas diffusion model.and the optimized formulation followed peppas order of release kinetics.
Keywords: Terbutaline sulphate, Floating microbeads.