Jyothi Rani L*1, K. Abbulu2
1Mallareddy Institute of Pharmaceutical Sciences, Dhulapally, Secunderabad-14, India
2Professor & Principal, Nova college of pharmaceutical education and research, Hyderabad, India
The Fast Dissolving Drug Delivery Systems was an advancement that came into existence in the early 1970’s and combats over the use of the tablets, syrups, capsules which are the other oral drug delivery systems. Fast Dissolving Drug Delivery Systems serves as a major benefit over the conventional dosage forms since the drug gets rapidly disintegrated & dissolves in the saliva without the use of water. In spite of the downside i.e, lack of immediate onset of action; these oral dosage forms have beneficial purposes such as self medication, increased compliance, ease of manufacturing and lack of pain. A variety of FDDs like mouth dissolving tablets and fast dissolving film (FDFs) were commercialized. FDFs evolved over the past few years from by the confection and oral care market in the form of breath strips & became a novel & widely accepted form by consumers. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Fast disintegrating tablets (FDTs) have received ever- increasing demand during the last decade and the field has become a rapidly growing area in the pharmaceutical industry because of such tablets readily dissolve or disintegrate in the saliva generally less than 60 seconds. The aim of the present study is to formulate and evaluate the mouth dissolving tablet and film of Saxagliptin with different ratios of polymeric combinations by the solvent evaporation technique. Saxagliptin is a new peptidase 4 (DPP-4) inhibitor and is used for the treatment of Diabetes mellitus. The drug is formulated as different formulations Tablet formulations named as F1 to F15, Film formulations named as F1 to F9 and studied for Thickness, mean weight(mg), drug content(mg),% hydration, %moisture loss , surface PH, Tensile strength, %elongation at break, folding endurance, mucoadhesion time, disintegration time. And these are also studied for In vitro dissolution studies. Among all the film and Tablet formulations F5 film formulation with combination of polymers (1:1) showed maximum release of 98 % in 15min emerging to be ideal formulations.
Keywords: Fast dissolving drug delivery system, fast dissolving oral tablet, fast dissolving oral film, PVP K 30,Polyvinyl alcohol, Saxagliptin.