Formulation and Evaluation of Fast Dissolving Buccal Tablets of a Model Non-Dihydropyridine Calcium Channel Blocking Drug

Mithun Bhowmick*, Nilesh Soni, Ghanshyam Sahu, Vivek Asati, Vaishali Rathi, Jagdish Rathi
NRI Institute of Pharmaceutical Sciences, 3, Sajjan Nagar, Raisen road, Bhopal, MP, India

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Hypertension is a major cause of concern not just in the elderly but also in the youngsters. In today’s research of oral drug delivery systems for hypertension, tablet dosage forms are supplanted by new drug delivery system because of problems like hepatic metabolism, GI toxicity and enzymatic degradation which leads to non-compliance and ineffective therapy. These problems can be overcome by formulating the drug into fast dissolving buccal tablets for oromucosal absorption with fast onset of action and improved bioavailability. The aim of the present study was to prepare and characterize mouth dissolving tablet of Diltiazem hydrochloride using super disintegrants like (sodium starch glycolate, crosscarmellose and crosspovidone)and developing a suitable dosage form, exhibiting a maximum disintegration in the mouth in order to provide good or dispersible formulation for rapid dissolution of drug and absorption which may produce the rapid onset of action.
Keywords: Buccal tablets, sodium starch glycolate, crosscarmellose and crosspovidone