Yogesh Joshi*, Ratendra Kumar Chaudhary, U.V.S. Teotia
Himalayan Institute of Pharmacy & Research, Rajawala, Dehradun, Uttarakhand, India.
Meerut Institute of Engineering & Technology, Meerut, Uttar Pradesh, India.
Shri VenkateshwaraUniversity, Gajraula, Uttar Pradesh, India.
The aim of the study was undertaken to find out the potential of gum from the fruits of Aegle marmelos to act as a release modifier in the formulation of diclofenac sodium sustained release matrix tablets. Purified isolated gum was subjected to physicochemical characterization. Four formulations containing Aegle marmelos gum with each containing 100mg of Diclofenac sodium were prepared by wet granulation method using different drug: gum ratios viz. 1:0.25, 1:0.5, 1:1 and 1:2. Microcrystalline cellulose was used as diluent while magnesium stearate and talc were employed as lubricant and glidant respectively. The prepared formulations were evaluated for pre-compression parameters relevant to granules like angle of repose, bulk density, tapped density, hausner’s index and carr’s index while tablets were evaluated for various post-compression parameters like tablet thickness, hardness, weight variation, friability, content uniformity, disintegration time, swelling behaviour and in-vitro drug release study. All the formulations showed compliance with pharmacopoeial standards and found to be within the limits as per the standards. Among all the formulations, AM-4 showed a slow and complete drug release of 98.86% over a period of 12 hr and thereby exhibited a satisfactory sustained drug release phenomenon.
Key words: Diclofenac sodium, Aegle marmelos, Sustained release