Formulation and Evaluation of Controlled Release Drug Delivery System

Pawan Kumar Battu, Amit Kumar Tiwari, Tribhuvan Singh and Naga Lasxmi*
Gurunanak Institutions Technical Campus, School of Pharmacy, Ibrahimpatnam, Telangana, India.

A B S T R A C T
In the present work, an attempt has been made to develop sustained release tablets of Itraconazole. Different gradess of Carbopol polymers used. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations, F4 formulation showed maximum % drug release i.e., 97.55 % in 8 hrs hence it is considered as optimized formulation. The F4 formulation contains Carbopol 934 in the concentration of 50 mg.
Keywords: Itraconazole, carbopol, controlled release.