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Bharghava Bhushan Rao P*, Lakshmana Rao A1, Sravani T2, Chandana M3, Vaseem unnisa4
*1,2,3,4V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India.
A B S T R A C T
The intention of the study was to formulate a stable multiple emulsion system containing two skin antiaging agents using a natural oil vitamin C, known to be a very unstable ingredient and is decomposed in the presence of oxygen, was entrapped in the internal aqueous phase of w/o/w multiple emulsions. In this way, vitamin C is expected to exhibit slow release and the effect of vitamin C can be improved as it has been protected from the external environment. The other ingredient, which is a product of wheat protein was also used as an antiaging agent. Both of the ingredients increase the synthesis of collagen fibers in the dermis. Therefore, a synergistic effect can be produced by using the two ingredients in one formulation. In this study, multiple emulsions were prepared by the two-step emulsification method. Basic formulation containing no active material and a formulation containing vitamin C in the internal aqueous phase and wheat protein in the oily phase were prepared. The oil selected was Olive oil since it consists mainly of oleic acid (up to 83%), with smaller amounts of other fatty acids including linoleic acid (up to 21%) and palmitic acid (up to 20%) which is the natural ingredient of the young skin. Basic formulation as well as the formulation containing active ingredients were stored at different accelerated conditions for six months and characterized. Globule size, pH, viscosity and physical changes were tested to characterize the emulsion systems. Basic emulsion was found to be more stable at all the different conditions than the formulation containing the active ingredients.
Keywords: Multiple emulsion, Vitamin C, Wheat protein, Physical properties
