Thursday , 18 August 2022

Female Antifertility Activity of Leonotis Nepetifolia in Wistar Albino Rats

Musale Jayesh Vasudeo1, I. Sarath Chandiran*2, P.D.  Chaudhari3
1Research Scholar, PRIST University, Thanjavur, Tamilnadu, India.
2Professor, Ratnam Institute of Pharmacy, Pidathapolur 524346, SPSR Nellore Dt, A.P, India.
3Principal, Modern College of Pharmacy, Nigdi, Pune.44, Maharashtra, India

A B S T R A C T
Leonotis nepetifolia is a folk medicinal plant with antifertility potentials. Present investigation is to study the effect of ethanolic extract of whole plant of Leonotis nepetifolia on hormone and reproductive parameters of female rat. Ethanolic extract of plant was administered orally to female rat for 20 consecutive days. Estrous cycle, reproductive hormones (LH, FSH and progesteron) and weight of reproductive organ were studied in both control and extract-administered groups by using standard methods. The female albino rats after oral administration of different doses of ethanolic extract of Leonotis nepetifolia showed a significant antifertility activity. FSH and LH level was significantly decreased in both drugs while amount of progesteron in ethanolic extract of high dose treated animals was found to be increased.The extract decreases the weight of ovary and increases the body weights. Based on the evidenced results it was concluded that ethanolic extract of whole plant of Leonotis nepetifolia cause endocrinological and physiological changes in the reproductive system of female albino rats after oral administration of different doses of ethanolic extract which justifies for its anti fertility activity.
Keywords: Serratiopeptidase, Serratia marcescens, Matrix tablets, Ethyl cellulose, Hydroxy propyl methyl cellulose.

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