Jagadesh Kumar Yadav Kalluri*1, R. Rajalakshmi1, EM. Ramya Sudha1,
Kiran kumar reddy B1, Bhagyasree. Y1, Mohan Kumar Atluri1, Subbarayudu.B2
1Deparment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A.Rangampet, Tirupati, A.P
2Department of Pharmaceutics, Sreenivasa College of Pharmacy, Proddature, Kadapa, A.P, India.
Labetalol hydrochloride is used as prevention of hypertension. It is having low bioavailability and high hepatic first pass metabolism. In the present work was Fast dissolving buccal films of Labetalol hydrochloride were prepared by solvent casting method with objective to improve the bioavailability, Patient compliance and Onset of action by using water soluble polymers like HPMC E-15(Hydroxypropyl methylcellulose), PVP K-30(Polyvinyl pyrrolidine) with the combination of PEG-400 (Polyethylene Glycol) as a plasticizer and glycerine used as sweetening agent.before the formulation the drug and polymer interaction was studied by FT-IR Analysis. The prepared films were evaluated for weight variation, surface pH, folding endurance, drug content uniformity, dissolving time, disintegration time, in-vitro drug release studies. From the evaluation study F3 formulation containing drug and polymer (1:3 ratio) showing good folding endurance and as well as increased controlled release of drug 94.35%. The present study concluded that fast dissolving buccal film formulation for poorly water soluble drugs for promising drug release and onset of action.
Keywords: Labetalol hydrochloride, HPMC E-15, Buccal films, in-vitro studies, PEG 400.