Saturday , 8 May 2021

Evaluation of Wound Healing Activity of Ethanolic Extract of Areial Parts of Cardiospermum Helicacabum LinnIn Albino Rats

Dinesh.A*, Dr. Jayasankar Reddy G
Department of Pharmacology, Krishna Teja Pharmacy College, Tirupati-517506, Andhra Pradesh, India.

Cardiospermum halicacabum (Linn) popularly called as balloon wine belongs to Sapindaceae family. Phytochemical constituents such as flavones, apigenin, triterpenoidal glycosides fatty acids and volatile ester have been reported in C. halicacabum. In the present study the aerial parts of C. halicacabum were studied for wound healing activity by incorporating extract in simple ointment base B.P. in concentration of 2% (w/w) and 5% (w/w) in rats through excision wound model. The statistical data indicated that the wound with ointment containing 5% w/w alcoholic extract exhibited significant (P < 0.001) wound contracting ability and period of epithelization. The experimental data demonstrated that C. halicacabum displayed remarkable wound healing activity.

Keywords: C. halicacabum, Alcoholic extract,Excision wound model, wound clousure, tissue regeneration, soframycin.

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