I. Sarath Chandiran1, K. B. Chandra Sekhar 2, Deepak Kumar*3
1Ratnam Institute of Pharmacy, Nellore- 524346, SPSR Nellore Dist, A.P, India.
2Oil Technological Research Institute, JNTUA, Ananthapuramu-515001, A.P, India.
3Gokula Krishna College of Pharmacy, Sullurpeta -524121, Nellore Dist, A.P, India.
A B S T R A C T
Accordingly, the present study was carried out to evaluate anti-oxidant and hypoglycemic activity of aerial parts of aqueous and ethanolic extracts of Delonix elata (AEDE & EEDE) on normal as well as hyperglycemic Wistar Albino rats. The antioxidant capacity was evaluated in both models of in vitro and in vivo with standard procedures. The hypoglycemic activity was evaluated by normal glucose and oral glucose tolerance test (NG-OGTT) method by administration of AEDE & EEDE at doses of 200 and 400 mg/kg body weight in streptozotocin (STZ) induced hyperglycemic rats. Evaluation of antioxidant activity of Delonix elata revealed that it shows moderate free radical scavenging activity. In In vivo study, treatment with ethanolic extract at 400 mg dose shows a significant increase (p<0.05) in the levels of superoxide dismutase (SOD) and catalase (CAT) and a significant decrease (p<0.05) in the levels of thiobarbituric acid reactive substances (TBARS), when compared to aqueous extract treated and CCl4 treated groups in both liver and kidney. In NG-OGTT method, EEDE of 400 mg shows reduction in glucose levels in glucose loaded hyperglycemic rats and also in STZ-induced hyperglycemic rats. Overall, the data suggested that the aerial parts of Delonix elata is a source of natural antioxidants and hypoglycemic properties.
Keywords: Anti-diabetic activity, Anti-oxidant activity, Delonix elata, Ethanolic extract.