Wednesday , 22 September 2021

Evaluation of Cardioprotective Activity of Ethanolic Extract of Leaves of The Cyanthillium Cinereum Against Isoprenaline Induced Cardiotoxicity In Rats

1Varukolu Soundarya*, 2Chintala Swetha Bindu, 3Dr. Challa Pradeep Kumar, 4Porandla Ravali
Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar, Telangana 505001.

The present study was aimed at evaluating the hepatoprotective activity of Bauhinia acuminata.L against Carbon tetra chloride induced hepatotoxicity in rats. Hepatic damage was induced by administration of CCL4 (1.5ml/kg b.w, i.p) in combination with olive oil (1:1) as a single dose. The extent of liver damage was studied by measuring liver tissue damage markers like SGOT, SGPT, ALP & BILIRUBIN (TOTAL & DIRECT) levels. Bauhinia acuminata.L showed the hepatoprotective activity by lowering CCL4 induced elevation of SGOT, SGPT, ALP  & BILIRUBIN levels (p<0.01) and was confirmed by the histopathological examination of liver tissues treated with test compound. This result strongly supports the protective effect of EEBA against liver injury.

Keywords: Bauhinia acuminata.L, Hepatoprotective, CCl4, Silymarin, Hepatotoxicity.

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