Efficient Ultrasound Synthesis and Antimicrobial Studies of Novel Schiff Bases of Isoniazid

Ganesh S. Kulkarni, Priyanka L. Anandgaonker, Sidharth D. Janrao, Digambar D. Gaikwad and
D. M. Janrao^*
1Department of chemistry J.E.S. College Jalna-431203
²Deptment of Chemistry, Govt. College of Arts & Science, Aurangabad-431001

A B S T R A C T
Hydrazones possessing an azometine -NHN=CH– proton constitute an important class of compounds for new drug development. In the present protocol we have synthesized six INH hydrazide-hydrazones by reacting isoniazid with various aldehydes by conventional as well as ultrasound irradiation method. The synthesized compounds were evaluated for antimicrobial activities. Utilization of ultrasound irradiation, simple reaction condition, isolation and purification makes this manipulation very interesting from an economic and environmental perspective.
Keywords: Ultrasound irradiation, Conventional method, INH hydrazide-hydrazones, Antimicrobial activities