Dr. D.K. Sanghi and Rakesh Tiwle*
Shri Laxmanrao Mankar Institute of Pharmacy, Amgoan, Gondia, Maharashtra, India- 441902.
Interpenetrating network (IPN) beads of sodium carboxymethyl xanthan and pectin were prepared by ionotropic gelation method using AlCl3 as a cross-linking agent. The Diltiazem Hydrochloride loaded beads were produced by the dropwise addition of the mixture of drug, sodium carboxymethyl xanthan and pectin into AlCl3 solution of different pH (2, 4, 6 and 8). Diltiazem Hydrochloride is a calcium channel blocker belonging to the benzothiazepine family. It is widely prescribed for the treatment of hypertension and angina. Bioavailability of Diltiazem Hydrochloride is 30 to 40% owing to an important first pass metabolism. Therefore, it is a suitable model candidate for sustained release formulation. The entrapment efficiency of the drug was carried out in pH 6.8 buffer solution. It was observed that the entrapment efficiency of the beads increased from 19.51% to 50.80% by increasing the pH of the AlCl3 solution from 2 to 8. Drug release studies showed that beads prepared with the drug in buffer solution provided some sustained release characteristics.
Keywords: Diltiazem HCl, IPN Beads, Drug Entrapment, Swelling Ratio, Drug Release