*Raval Kashyap1, U.Srinivasa2
1Research Scholar, Department of Pharmacy, Pacific University, Udaipur
2Head of Department, Srinivas College of pharmacy, Mangalore
A B S T R A C T
Colorimetric methods have been developed for the estimation of Ketotifen& Pioglitazone. Here Methods were based on reaction involving the formation of green colored complex with Potassium permanganate. The maximum absorbance of the solution was measured at 616 nm& 602 nm against blank respectively. The calibration curve calculated obeys Beer’s law over the concentration range of 25-45 & 20-40µg/ml.The method was validated based on ICH guidelines. The high recovery and low relative standard deviation confirms the suitability of the method for determination Ketotifen& Pioglitazone. Hence it is useful for the routine analysis of Ketotifen and Pioglitazone.
Keywords: Ketotifen, Pioglitazone, 0.1N NaOH, UV spectrophotometric and validation parameters.