Wednesday , 22 March 2023

Design and In-Vitro Characterization of Oxymorphone Tablets for Controlled Release Drug Delivery System

Amareshwar Shabada1, Yellanki Prashanthi2
1Assistant Professor, Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi, Pochampally, Yadadri, Telangana-508284
2Assistant Professor, Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi, Pochampally, Yadadri, Telangana-508284

Attempt has been made to develop controlled release tablets of Oxymorphone by using xanthan gum, karaya gum, guar gum as polymers. Nine formulations were prepared by taking different concentrations of polymers. All the formulations were prepared by direct  compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits Compared to all formulations F3 formulation showed maximum % drug release i.e., 98.56 % in 12 hours hence it is considered as optimized formulation.

Keywords: Oxymorphone, xanthan gum, karaya gum, guar gum.

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