Design, Synthesis and Evaluation of Anti-Depressant Activity of Some New Oxadiazol derivatives of Phenothiazine

Nachiket S. Dighe^*, Arun B. Tambe, Santosh S Dengale, Amol S Dighe
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, India-41373

A B S T R A C T
There has been considerable interest in the development of novel compounds of some new oxadiazole fused Phenothiazine derivatives containing heterocyclic moiety. Many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new phenothiazines that possess varied biological activities. The synthesized compounds were tested for their preliminary tests, physical constants, TLC, IR, ¹H-NMR Spectra and CHN analysis confirmed the structures of the final compounds. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A₄, A₅, A₇) showed significant antidepressant activity comparing with control drug imipramine. These results are useful for the further investigation in the future.
Keywords: Antidepressant activities, Despair swim test, Phenothiazine and Sprague Dawley Rats.