Sreekanth Babu S*, Ajay Kumar A, Suman D R, Parvathi M
Department of Pharmaceutics,
Ragavendra Institute of Pharmaceutical Education and Research, Anantapur, A.P, India.
E-mail: [email protected]
Moxifloxacin hydrochloride has a short elimination half-life, a narrow absorption window and is mainlyabsorbed in proximal areas of GIT. The purpose of this study was to develop a gastroretentive controlledreleasedrug delivery system with swelling, floating, and adhesive properties. Ten tablet formulationswere designed using hydroxypropylmethylcellulose (HPMC K15M) and/or sodium alginate (Na alginate)as release-retarding polymer(s) and sodium bicarbonate (NaHCO3) or calcium carbonate (CaCO3) as a gasformer. Swelling ability, floating behaviour, adhesion period and drug release studies were conducted in0.1 N HCl (pH 1.2) at 37 ± 0.5 _C. The tablets showed acceptable physicochemical properties. Drug releaseprofiles of all formulae followed non-Fickian diffusion. Statistical analyses of data revealed that tabletscontaining HPMC K15M (21.42%, w/w), Na alginate (7.14%, w/w) and NaHCO3 (20%, w/w) (formula F7)or CaCO3 (20%, w/w) (formula F10) were promising systems exhibiting excellent floating properties,extended adhesion periods and sustained drug release characteristics.
Keywords:Moxifloxacin hydrochloride, gastroretentive controlledreleasedrug delivery system, release-retarding polymer.