Combined effect of Coenzyme Q10, Riboflavin, Niacin, Selenium (CoRNS) and Emblicaofficinalis studied on experimental atherosclerosis in rats

U. Indumathi¹*, T.P. Sachdanandam^2
1Department of Biochemistry, T.S.Narayanaswami College of Arts and Science, University of Madras, Chennai-600130.
²Department of Pathology, Dr. ALM. PGIBMS, Taramani, Chennai-600113.

A  B  S  T  R A C T
Cardiovascular diseases are becoming more prevalent in the world.  Atherosclerosisis one of the most widespread and leading diseases which causes death in most developed countries. The present study is aimed at bringing about the anti-atherogenic effect of the herbal drug, Emblicaofficinalis in combination with natural respiratory antioxidants viz., Coenzyme Q10, Riboflavin, Niacin and Selenium (CoRNS) in a high cholesterol (HCD) induced atherosclerotic rat model. The HCD brought changes in the activity of the lipid metabolizing enzymes and membrane bound ATPases in the rats. Upon treatment with CoRNS and Emblicaofficinalis, the activity of the enzymes was brought to normal.
Key words: Lipid, lipid metabolizing enzymes, ATPases, cardiovascular disease.