A. Srikanth1*, Y. Prasanna Raju2, N. Devanna3, Kambham Venkateswarlu4
1Department of Pharmacology, Oil Technological Research Institute, Anantapur-515001, A.P, India.
2Department of Pharmaceutics, Sri Vidyanikethan College of Pharmacy, Tirupati-517102, A.P, India.
3Department of Chemistry, Oil Technological Research Institute, Anantapur-515001, A.P, India.
4Department of Pharmaceutics, Oil Technological Research Institute, Anantapur-515001, A.P, India.
The main aim of this review is “how to target the Rheumatoid Arthritis by Pulsatile Drug Delivery System through chronopharmacokinetic information”. The patients who are suffering from Rheumatoid Arthritis will have pain at morning time. Due to this chronopharmacokinetic studies, this gives the information about variation in drug plasma levels as a function of time usually 24 hours and the mechanism responsible for that time dependent variation. So now the targeted drug delivery will happen in that patients and they will be free from the pain rapidly. PDDS releases the drug for prolonged period of time, especially after the lag time.
Key words: Chronopharmacokinetics, Rheumatoid Arthritis, PDDS.