Sushma B.J*, Nagarajappa K, Shrikant Chandrakar
Department of Biochemistry, S.S. Institute of Medical Sciences and Research Centre, Davangere, India.
Polycystic ovary syndrome (PCOS) is one of the most common female metabolic endocrine disorder. It affects about 5-10% of women of reproductive age. It is thought to be one of the leading cause of female infertility. Women with PCOS demonstrate hormonal disturbances and serum lipid derangements. To determine and evaluate the association of thyroid stimulating hormone (TSH) with body mass index (BMI), insulin resistance (IR) and lipid profile parameters. To identify the cut-off value of TSH at which the association between TSH and IR exists. In this study we included 60 diagnosed cases of PCOD as per Rotterdam’s criteria and 60 healthy age matched healthy controls from whom fasting blood sample was drawn to measure fasting insulin, free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), leutanizing hormone (LH) and prolactin levels by Chemiluminiscence immuno assay. Insulin resistance was calculated by employing homeostasis model assessment of insulin resistance (HOMA-IR). Lipid profile parameters (total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL) and triglycerides (TG)) were measured using automated clinical chemistry analyzer according to manufacturer’s protocol. Women with high TSH (>2.5 mIU/L) levels were more insulin resistant as compared to women with low TSH (< 2.5 mIU/L). A significant association between increased TSH and IR was found in women with PCOS and the association was independent of body mass index (BMI).
Keywords: Polycystic ovarian disease, Thyroid stimulating hormone, Freetriiodothyronine, Free thyroxine & Insulin resistance.