Krishnaveni Manubolu*1, K. Sruthi2, M. Sreenivasulu3
1Department of Pharmaceutics, Narayana Pharmacy College, Nellore, Andhrapradesh-524002.
2Department of Pharmaceutics, Narayana Pharmacy College, Nellore, Andhrapradesh-524002.
3Department of Pharmaceutical chemistry, Narayana Pharmacy College, Nellore, Andhrapradesh-524002.
A B S T R A C T
This review gives information on resolvins and related substances, which are important both as endogenous proresolvers and as therapeutic candidates preventing deterioration of inflammation and pathologic pain. Inflammation is the first response of the immune system to injury or infection. This way the immune system protects the body from infection or injury. Inflammation is an essential biological process for maintenance of homeostasis and recovery from tissue injury or foreign pathogens. Resolvins block the production of pro-inflammatory mediators and regulate leukocyte trafficking to inflammatory sites as well as clearance of neutrophils from mucosal surfaces. Also limitation of polymorph nuclear leukocyte migration and infiltration across the endothelium is done by resolvins. Pain an important aspect of inflammation, may be strongly affected by the actions of resolvins. Resolvins may also directly regulate the function of the sensory neural circuit, independent of their control mechanisms for the inflammatory state. RvE1 is a local acting autacoid that has proved to display pro-resolving activity when treatments were given either by topical, intra venous, or intra peroneal administration.
Keywords: Resolvins, Inflammation, pharmaceutical, pain