Alpesh Yadav1*, Isha Shah1, Patel Chirag J1, Patel Harnish K2, Patel Priyanka H3
1Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India-302020.
2Editor-In-Chief, IJPRBS Journal, Gujarat, India.
3Director, Research Scholar Hub, Gujarat, India
Poorly soluble, highly permeable active pharmaceutical ingredients represent a technological challenge because their poor bioavailability is only caused by poor water solubility resulting in low drug absorption. Newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor aqueous solubility. Problem of solubility is a major challenge for formulation which can be solved by different technological approaches during the pharmaceutical product development and to improve water solubility and drug release respectively, among which the liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. With this technique liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders by simple physical blending with selected excipients named the carrier and the coating material. It has been speculated that such systems exhibit enhanced release profiles.
Keywords: Liquisolid technology, liquid load factor, solubility, carrier material, coating agent.