Monday , 25 January 2021

1H-1, 2, 4,-Triazole Having Significant Pharmacological Activities

Author Details
Sakshi Gupta*, Dharmendra Kumar
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
Baghpat bypass crossing, NH-58, Delhi-Roorkee, Highway, Meerut-250005, U. P., India

In the last few years, heterocyclic compounds have attracted strong interest and a lot of work has been done on triazole ring. Many different derivatives have been prepared from it which possesses useful pharmacological activities. In the present review, we have compiled the different pharmacological activities of triazole ring and its derivatives. It has been observed that triazole derivatives possess a wide range of pharmacological activities such as anticancer, anticonvulsant, antimicrobial, anti-inflammatory, antioxidant, antitubercular, antimalarial, antinociceptive etc. In triazole ring, substitution at 1, 4 and 1, 3 positions of a more electronegative group will possess more active analogues. This review contains various pharmacological activities of triazole in one place and it is also the milestone for the new research towards this moiety.
Key words: Triazole, anticancer,  anticonvulsant, Antimicrobial, Anti-inflammatory

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