Namrata Sharma*, RD Patil, Ajay Thakur, VK Gupta
Department of Veterinary Pathology, College of Veterinary & Animal Sciences,
CSK Himachal Pradesh Krishi Vishvavidyalaya, Palampur-176062, H.P, India
Wound healing is an important biological process involving tissue repair and regeneration that results in restoration of tissue integrity. The present study was undertaken in Sprague dawley male rats to evaluate the healing efficacy of leaf extract of H. rhaminoides (HR) and compared to reference control (Povidine iodine) and placebo control (Propylene glycol) using full thickness excised wound model. Animals were divided into three groups and were applied Propylene glycol, Povidine iodine solution, 1% (w/w) HR leaf extract once daily on the 4mm and 8mm full thickness excised wounds. Percentage wound contraction measured after every 2 days interval revealed that HR had significantly (P<0.05) faster reduction in wound on day 2, 4, 6, 8 in comparison to other groups. HR showed significant anti-inflammatory response, angiogenesis and proliferation of the fibroblast maturation. The histological examination confirmed superior healing efficacy of the HR. H. rhaminoides leaf extract was found to be superior for wound healing when compared to Povidine iodine.
Keywords: H. rhaminoides, wound healing, angiogenesis, epithelisation.