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B. Mohammed Ishaq*, Hindustan Abdul Ahad, Shaik Muneer, K. Anil Kumar, P. Satya Sowmya, S. Praveena
Department of Pharmaceutical Analysis, Balaji College of Pharmacy, Anantapuramu, A.P India
Abstract: A simple, rapid, sensitive and reproducible visible spectro- photometric method has been developed for the determination of Lamotrigine (LMG) in bulk and in its dosage forms. The method is based on the reaction of LMG with gold (III) chloride in the pH range 2.5 – 3.5 forming Yellow color complex solution, showing absorption maxima at 400 nm. The linear plot indicates that Beer’s law is obeyed in the range of 10 – 160 μg/ml of LMG. The molar absorptivity and Sandell’s sensitivity are 1.3896 x 103 l mol-1 cm-1 and 0.0184 μg/cm2 respectively. The standard deviation of the method for ten determinations of LMG is 0.0013. The correlation coefficient (r2) of the experimental data of the calibration plot is 0.9999. The effective range of concentration for accurate determination of LMG as ascertained from Ringbom’s plot and it is 10 – 160 μg/ml. Interferences of the other ingredients and excipients were not observed. The optimum reaction conditions and other analytical parameters were evaluated. The methods were successfully applied to the determination of LMG in pharmaceutical formulations
Key words: Lamotrigine, Gold Chloride, Sandell’s, Sensitivity, Yellow color complex
