Various Synthesis Methods of 1,3,4-Oxadiazolederivatives: A Review

M Somashekhar*, R B Kotnal
Department of Pharmaceutical Chemistry, Bldea’s College of Pharmacy, Vijaypur-586101.

A B S T R A C T
Heterocyclic molecules such as Oxadiazoles have been synthesized and evaluated for medical and agricultural activities. The disubstituted Oxadiazoles have executed a range of pharmacologic activities. 1,3,4-oxadiazole and 1,2,4-oxadiazole are better known, and more widely studied by researchers Among heterocyclic compounds, 1,3,4-oxadiazole has become an important construction moiety for the development of new drugs.1,3,4-oxadizole exhibited a wide range of biological activities which includes antimicrobial, anti-tubercular, anticonvulsant, hypoglycemic, anti-allergic, vasodilator, anti-inflammatory, analgesic, anthelmintic, anticancer, antiviral, antioxidant, hemolytic, antiprolifrative activities etc. The purpose of this review is to collect the literature work reported by researchers on 1,3,4-oxadiazole derivatives for their various methods of synthesis and also efforts made on this moiety.
Keywords: 1,3,4-oxadiazole, 1,2,4-oxadiazole, synthesis methods, biological activities