Wednesday , 30 September 2020

The Evaluation of Combine Drug Action of Codeine as Supplementary Drug with Dakin-West β-Acetamidoketones

Deepak. M. Nagrik*
Department of Chemistry, G.S. Science, Arts and Commerce College, Khamgaon-444303, M.S., India

A B S T R A C T
β-acetamido ketones were synthesized in high yields under mild condition via four component Dakin-West  reaction which carried out by condensation of aromatic aldehydes, enolizable ketones, acetonitrile and acetyl chloride in presence of mixed metal oxide CuO-SnO2 as versatile catalyst. The biological study of compounds codeine was used as supplementary drug in combination of the resultant Dakin-West compounds. Interesting results were obtained in accordance with the principle of ‘Synergism’. It was observed that, synthesized β-acetamidoketones and supplementary drug, Codeine worked together to produced results which were not independently obtainable.
Keywords: Combine drug action, Dakin-West reaction, Synergism, Supplementary drug, Codeine.

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