Saturday , 25 November 2017

The Emerging Role of Plant Derived Therapeutic Compounds for Targeting Inflammatory and Oxidative Stress Related Pathways

Krishna Chaitanya Karri1*, Kamalakararao Konuku1, Patricia Ponce-Noyola2, John Dogulas Palleti2, Venugopal Reddy Bovilla3, S.B. Padal4, Rajyalakshmi Amancherla5, Anjali jha6, Dr. M. Muthulingam7,Govinda Rao Duddukuri1
1Department of Biochemistry, Institute of Science, GITAM University, Visakhapatnam, A.P, India.
2Department of Life Sciences, University of Guanajuato, Mexico.
3Department of Biochemistry, JSS Medical College, JSS University, Mysore.
4Department of Botany, Andhra University, Visakhapatnam, Andhra Pradesh, India.
5Director, Bio world research technologies, Hyderabad, Telangana, India.
6Department of Chemistry, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India
7Assistant Professor of Zoology, Faculty of Science, Annamalai University, Tamilnadu, India

A B S T R A C T
Medicinal plants are extensively used in folk medicine for treatment of acute and chronic inflammatory diseases. The secondary metabolites, which are present in medicinal plants such as flavonoids, terpenoids, xanthones and coumarins, are responsible for anti-inflammatory activities by targeting arachidonic acid dependent and independent pathway. Based on the invitro and invivo anti-inflammatory studies ethanopharmacologists screened the various medicinal plants for their anti-inflammatory activities. The selected medicinal plants further subjected to activity guided fractionation.  The bioactive fractions were further subjected to structural elucidation studies for characterization of bioactive compounds. 
Keywords: Anti-inflammatory agents, cyclooxygenase (COX-2), Nuclear factor kappa B (NF-κB), phytocompounds, Reactive oxygen species (ROS), antioxidants, activity guided fractionation

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