Tuesday , 27 October 2020

The Bioactive Compounds obtained from the Tomatoes (Solanum lycopersicum L.) act as Potential Anticancer agents against the Human Cervicle Adenocarcinoma

Asish Bhaumik*1, M. Upender Kumar1, P. Sravan Kumar2Kaleem Ahmed Khan2, Ch. Srinivas3
1Department of Pharmaceutical Chemistry, Teja College of Pharmacy, Kodad, Nalgonda-508206, Telangana, India.
2Department of Pharmacology, Teja College of Pharmacy, Kodad, Nalgonda-508206, Telangana, India.
3Department of Pharmaceutical Analysis, Teja College of Pharmacy, Kodad, Nalgonda-508206, Telangana, India.
NCADDD, 25 July 2014, Organized by Department of Pharmaceutical Technology, Anna University, BIT Campus, Tiruchirappalli–620024, Tamil Nadu, India

Abstract
Tomato (Solanum lycopersicum L.) is one of the most important vegetables worldwide because of its high consumption, year round availability and large content of health related bioactive compounds. Tomatoes contain a variety of bioactive compounds such as lycopene, vitamin-C, quercetin, naringenin, chalcone and chlorogenic acid and others health protectives like amino acids, phytosterols, amines and carbohydrates etc. The extract was prepared by reflux condensation method. The objectives of the present work are to search anticancer activity. Based on this,a new series of constituents have been planned to extract by Methanol (E1), Ethanol (E2), Acetone (E3), and chloroform (E4) a from ripen tomatoes. The in-vitro anticancer studies were performed against human cancer cell line (HeLa) and MTT assay was used to analyze the cell growth inhibition and doxorubicin and dactinomycin were used as a standard antineoplastic agents. The results showed that the various extracts of tomato possessed a very good to moderate anticancer activity and the IC50 values of E1, E2, E3, and E4 extracts were found to be 63.3, 68.2, 57.5 and 62.1.
Keywords: Solanum lycopersicum L., Bioactive compounds, Lycopene, Anticancer, HeLa, MTT assay, IC50 etc.

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