Wednesday , 13 December 2017

Tag Archives: Solid dispersion

Determining the Best Poly Ethylene Glycol as Solid Dispersion Carrier for Improvement of Solubility and Dissolution Rate of Ofloxacin

B. Faheem, Hindustan Abdul Ahad, Shameena S, Mohammed Asif M, Meena M, Abdul Riyaz S Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India A B S T R A C T The present investigation was to find out the best polyethylene glycol (PEG) as carrier to increase solubility of poorly soluble drug by taking Ofloxacin as model drug. PEG 1500, ... Read More »

Formulation and Evaluation of Immediate Fenofibrate Solid Dispersions

Dipak K.Borole*1, Hemant V.Deore1, Tanvirahmad J. Shaikh1, Jayshri A. Patil2, Harshal S. Bhandari 1 1DCS’S A.R.A College of Pharmacy, Nagaon, Dhule 2NES’S Gangamai College of Pharmacy, Nagaon, Dhule A B S T R A C T The aim of the present research work, Fenofibrate a BCS class II Anti hyperlipidemic drug belongs to fibrate class was formulated as solid dispersions ... Read More »

Formulation and Evaluation of Orally Disintegrating Tablets of Zolpidem Tartarate

S. Rajeshwari*, Soma Sekhar. G, Nazemoon.R, Razia Sultana, Hamshida .P. Khanam, M.BiBi. Fathima Safa college of Pharmacy, Kurnool, Andhra Pradesh, India A B S T R A C T Zolpidem tartarate is a super disintegrating tablet. It achieves rapid dissolution, absorption and further improving the bioavailability of drug. It is formulations by in-vitro method and to select the best formulation ... Read More »

Preparation and Evaluation of Solid Dispersions of Pioglitazone Using Skimmed Milk Powder as Carrier

A. Hemanth*1, H. Abdul Ahad2 1V. L .College of Pharmacy, Manik Prabhu Temple Road, Raichur-584103, India. 2Balaji College of Pharmacy, Rudrampeta Bypass, Anantapur-515001, India. A B S T R A C T Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. The poor ... Read More »

Comparative study of different solvent extract of Olea dioica Roxb. Western Ghats, Karnataka, against selected plant and animal pathogenic bacteria

Ashwathanarayana.R*1, Raja Naika2  1Research student, Department of PG Studies and Research in Applied Botany, Jnanasahyadri, Kuvempu University, Shankaraghatta- 577451, Shimogga, district, Karnataka, India. 2Professor, Department of PG Studies and Research in Applied Botany, Jnanasahyadri, Kuvempu University, Shankaraghatta- 577451, Shimogga, district, Karnataka, India. A B S T R A C T Olea dioica Roxb. is a very important ethno medicinal evergreen tree ... Read More »

Development and Evaluation of Carvedilol Oral Disintegrating Tablet by Solid Dispersion Technique

Balachandrudu*, Somasekhar.G, Nazemoon.R, Raziya SMD. Department of Pharmaceutics, Safa College of Pharmacy, Kurnool, Andhra Pradesh, India A B S T R A C T Carvedilol is a poorly water soluble oral antihypertensive agent. An attempt has been made to develop fast dissolving the tablet of carvedilol by direct compression and solid dispersion technique the solid dispersion of carvedilol with peg-4000(1:4 ... Read More »

Development and Evaluation of Carvedilol Fast Disintegrating Tablet by using Superdisintegrants and Solid Dispersion Technique

Hyma.P*, Mahesh.M Scientific and Applied Research Center, Hyderabad, Telangana, India A B S T R A C T Carvedilol is a poorly water soluble oral antihypertensive agent. An attempt has been made to develop fast dissolving the tablet of carvedilol direct compression and solid dispersion technique the solid dispersion of carvedilol with peg-4000(1:4 molar ratio) by fusion extrusion method with ... Read More »

Ketoconazole Solubility Enhancement: Different Techniques and its Comparison

Author Details Ravi Prakash*, Shashi Shekhar Tripathi, Pravin Gupta, Rahul Dev, Anaagat Sir Madanlal Institute of Pharmacy Aalampur Hauz, Etawah-206001, U.P., India Abstract Four techniques namely melt sonocrystallization, solid dispersion, hydrotrophy and inclusion complex with cyclodextrin were used for the solubility enhancement. The order of the techniques for the solubility enhancement was found hydrotrophy>inclusion complex>solid dispersion>sonocrystallization method. Enhancement in the ... Read More »

Method used for Solubility Enhancement of Poorly water Soluble Drug-A Review

About author Prasad Harendra*, Verma Navneet Kumar Rameshwaram Institute of technology and Management Lucknow, U.P. India E-mail: navneet_its04@rediffmail.com Abstract The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the drug development process. Following oral administration, drugs with slow dissolution rates generally show erratic and incomplete absorption which may lead to therapeutic failure. The aim of ... Read More »

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