Thursday , 24 September 2020

Tag Archives: ICH guidelines

Method Development and Validation for the Simultaneous estimation of Velpatasvir and Sofosbuvir in tablet dosage form by using RP–HPLC

M. Anusha*, B.V. Ramana, G. Nagarajan Dr. K.V. Subba Reddy Institute of Pharmacy, Kunrool, Andhra Pradesh, India A B S T R A C T The present research work mainly focused on method development and validation for the simultaneous estimation of velpatasvir and sofosbuvir in tablet dosage form by using RP-HPLC. Chromatographic separation was carried on YMC C18 column (4.6*150mm, ... Read More »

Development of New RP-HPLC method for the estimation of Glycopyrrolate and Formoterol fumarate in the tablet dosage form

Damam Vidya*, B.V. Ramana, G. Nagarajan Dr. K.V. Subba Reddy Institute of Pharmacy, Kunrool, Andhra Pradesh, India A B S T R A C T The present research work mainly focused on method development and validation for the simultaneous estimation of Glycopyrrolate and Formeterol fumarate in tablet dosage form by using RP-HPLC. Chromatographic separation was achieved on Xterrra C18 column ... Read More »

Analytical Method Development and Vaidation for Ombitasvir and Paritaprevir in Combined Dosage Form by RP-HPLC

K.Nithiyananthan1*, K.V.S.Prasadarao2 1Research Scholar,  Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510. 2Principal, Rahul Institute  of Pharmaceutical Sciences And Research, Chirala, Andhra Pradesh 523157 A B S T R A C T Ombitasvir and Paritaprevir by using Thermosil C18 column (4.0×125mm) 5µ, flow rate was 1ml/min, mobile phase ratio was (70:30 v/v) methanol: Sodium acetate buffer pH 3 (pH was adjusted ... Read More »

Review on Analytical Method Validation Procedures

k. Surendra*, SK. Karishma, G. Obulesu, M. Naveena Rao’s College of Pharmacy, Chemudugunta, Venkatachalam, Nellore, Andhra Pradesh-524320 A B S T R A C T Pharmaceutical analysis plays a very prominent role in quality assurance as well as quality control of bulk drugs and pharmaceutical formulations, of which analytical method development & validation is the basic activity. Analytical techniques are ... Read More »

A Novel RP-HPLC Method Development and Validation for the Estimation of Pyrimethamine in Bulk and its Pharmaceutical Formulation

U. Srinivasulu*1, N. Devanna2, A. Sandhya 3, B. Siva Sai Kiran3, S. Muneer3 1Associate Professor of Chemistry, SBSYM Degree College, Kurnool-518004, A.P., India 2Professor and Director, Department of Chemistry, JNTUA-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515002, A.P., India. 3Department of Pharmaceutical Sciences, JNTUA-Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515002, A.P., India A B S T R A C T A simple, ... Read More »

A Simple Analytical Method Development and Validation for the Quantification of Darifenacin Hydrobromide in Pure and Its Tablet Dosage Form using UV-Spectrophotometry

A. Lakshmi Bhagya Sree*, B. Siva Sai Kiran, S. Muneer, K.B Chandra Sekhar Department of Pharmaceutical Analysis, JNTUA- Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515001, A.P, India. A B S T R A C T A simple, accurate and precise Zero order spectroscopy method was developed and validated for the estimation of Darifenacin Hbr bulk and pharmaceutical dosage forms.  Distilled ... Read More »

Method Development and Validation of Mycophenolate Mofetil by RP-HPLC

Rubina Kauser, M. Mushraff Ali Khan, Airaj Mahajabeen, Farhana Shaheen, Salma Begum MRM College of Pharmacy, Chintapalliguda, Ibrahimpatnam, R.R District-501510 A B S T R A C T Reversed-phase high-performance liquid chromatography (RP-HPLC) involves the separation of molecules on the basis of hydrophobicity. The separation depends on the hydrophobic binding of the solute molecule from the mobile phase to the ... Read More »

A New Validated Stability indicating RP-HPLC Method for the Quantitative Analysis of Phentermine Hydrochloride in Tablet Dosage Form

K.V. Lalitha*1, R. Kiranjyothi2 1Department of Pharmaceutical Analysis, Raghavendra Institute of Pharmaceutical Education and Research, Ananthapuramu – 515001, Andhra Pradesh, India. 2Department of Pharmaceutical Analysis, JNTUA – Oil Technological Research Institute, Ananthapuramu – 515001, Andhra Pradesh, India. A B S T R A C T A novel stability indicating RP-HPLC method was developed for the estimation of Phentermine hydrochloride in ... Read More »

Analytical Method Development and Validation for the Estimation of Efavirenz by RP-HPLC Method in Bulk and Pharmaceutical Dosage Form

Gobala Krishnan P*1, Munisekhar V, Ranjit Singh B. Rathore Department of Pharmaceutical Chemistry, Vagdevi college of Pharmacy & Research centre, Nellore, Andhra Pradesh, India. A B S T R A C T The chromatographic conditions were successfully developed for the separation of Efavirenz  by using KromosilColumn (100-5 C18.60×4.6mm), flow rate was 1ml/min, mobile phase ratio was Acetonitril: Phosphate buffer PH ... Read More »

Development and Validation of New UV Spectroscopic and HPLC Methods for the Estimation of Zidovudine in Bulk and Pharmaceutical Dosage Form

Telugu Naga Mohan, Shaik Mohammed Yusuf*, Seerla Eswaraiah, D. Chinna Raju, E. Vijay Kumar Srinivasa Institute of Pharmaceutical sciences, Proddatur, YSR Kadapa [Dist]. AP. India.  A B S T R A C T In the present work, two simple, sensitive and specific methods (UV Spectroscopy and RP-HPLC) have been developed for the quantitative estimation of Zidovudine in bulk and pharmaceutical ... Read More »

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