Saturday , 24 August 2019

Synthesis of the new carboxylic α,α-diamino ester: Methyl 2-benzamido-2-(N-benzyl N-ethylamino) acetate

El Houssine Mabrouk and Abdelilah El Hallaoui
Laboratory of Organic Chemistry, Faculty of  Sciences Dhar El  Mahraz, University  Sidi  Mohamed Ben  Abdellah,  B.P. 1796,  Fez,  Morocco

A B S T R A C T
A simple synthetic approach to racemic methyl 2-benzamido-2-(N-benzyl N-ethylamino) acetate in high yield is reported. This synthesis involves the N-alkylation reaction between methyl α-bromo glycinate or methyl α-azido glycinate N-benzoylated and N-benzyl-N-ethylamine in different solvents in the presence of various bases. The structure of this product was established on the basis of NMR spectroscopy (1H, 13C), and MS data.

Keywords: Amine; N-alkylation; α-Amino acids; Methyl α-azido glycinate, methyl α-bromo glycinate.

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