El Houssine Mabrouk
Laboratory of Organic Chemistry, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdellah, B.P. 1796, Fez, Morocco
Heterocyclic amino acids represent a well-known group of organic compounds also presenting biological activity. We developed an environmentally benign, efficient, and simple method for the Synthesis of new racemic α-tetrazolyl α-carboxylic aminoesters derivatives by nucleophilic substitution of methyl α-azido glycinate N-benzoylated with p-methoxyphenyl-1H-tetrazole. The structure of the these compounds have been characterized from the rigorous analysis of their spectral 1H-NMR, 13C-NMR and MS.
Keywords: Tetrazole, Nucleophilic substitution, α-Aminoesters, Methyl α-azido glycinate