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Synthesis, Characterization and Antioxidant studies of 2-Benzylthio benzimidazole derivatives

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Sumayya K K*, Kamalabhai Amma V K, Babu G, Biju C R
Department of Pharmaceutical Chemistry,
Devaki Amma Memorial College of Pharmacy, Pulliparamba, Chelembra, Malappuram, India-673 634.
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The present study was undertaken to evaluate the antioxidant activity of some Mannich bases of  2-benzylthio benzimidazole derivatives. Mannich bases of 2-benzylthio benzimidazole were synthesized by formaldehyde, 2-benzylthio benzimidazole and different amines. The physiochemical properties of the synthesized compounds were evaluated and were established by IR, 1HNMR, MASS spectral datas. The synthesized derivatives  showed good antioxidant activity by DPPH assay method.
Key words: O-phenelyne diamine, 2-Mercapto benzimidazole, 2-benzylthio benzimidazole, formaldehyde, DPPH assay method

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