Devanapelly Shashikantha Rao*
Lecturer, Department of Chemistry, C.K.M. Arts and Science College, Warangal- 506006, Andhra Pradesh, India.
Benzothiazole is an aromatic heterocyclic compounds with the general formula C7H5NS which consists of 5 membered hetero cyclic 1, 3 thiazole ring fused to benzene. Benzothiazole is a simple analogues which play a major role in research which has wide number of biological activities like antimicrobial, antitubercular, antimalarial, anticonvulsant, antihelimenthic, analgesic and anti-inflamatory activity. on the account of the reported anticancer activity of benzothiazoles containing pthalmide, a new series of benzothiazole derivatives were synthesized and tested for in-vitro anticancer activity against human carcinoma cell line. The newly synthesized compounds were screened for antibacterial activity against Gram positive [Bacillus subtilis (NCIM-2545), Staphylococcus epidermidis (NCIM-2493), Staphylococcus aureus (NCIM-5021)] and Gram negative [(Escherichia coli (NCIM-2803)] bacteria by agar diffusion method. All the compounds were found to be active against all the four bacterial strains at 20 µg/ml concentration. The compound 1,3-benthiazol-2-amine exhibited activity against Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis, at a concentration of 20 µg/ml. All the activity is done with Amoxicillin as reference
Keywords: Benzothiazole, analgesic activity, anti-inflamatory activity, Escherichia coli