Tuesday , 26 March 2024

Synthesis, Characterisation and Biological Evaluation of Novel 1,2,4 Oxadiazole Derivatives

Dr. P. Thriveni, M. Hari Krishna*, K. Murali
Department of Chemistry, Vikrama Simhapuri University, Nellore-524003, A.P, India.

A B S T R A C T
A series of  1,2,4 Oxa di azole  derivatives5 (a-g) were prepared by reaction of P-Substituted Aldehydes(4)  with hydroxyl amine hydro chloride in NMP & CDI ,DBU to get target compounds. The Structures of the Compounds are confirmed by IR, 1H NMR &13C NMR Spectral data, Elemental Analysis, Mass spectral data. The compounds are also evaluated for their anti microbial and antifungal activity, among them 5e& 5d are found as potent activity.  
Keywords: Synthesis, Antimicrobial & Anti Fungal Activity, 1,2,4 oxa di Azoles, NMP, CDI, DBU

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