Wednesday , 8 July 2020

Synthesis and Characterization of New Thiazolidinone Derivatives and Screening for Their Anti-Inflamatory Activity

About author
Pravesh Gangwar*, Dr.Pankaj Sharma, Dr. Birendra Shrivastava.Jaya Sharma, Shikha Sharma
Department of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
E-mail: pravesh.gangwar_pharma@yahoo.com

Abstract
In the present study, a thiozolidinones derivatives were synthesized by the 1-actynaphthalene. 1-actynaphthalene on brominating with chloroform gives 1-bromoactynaphthalene which was reacted with substituted benzaldehyde thiosemicarbazone in ethanol as a solvent give 4-naphthalen-1-yl-2-{2-[(substituted phenyl) methylidene] hydrazino}-1,3-thiazole.This compound on addition reaction with thioglycolic acid in presence of zinc chloride as a catalyst and dioxane as a solvent gives the final compounds. Their structure has been well characterized by physical and spectral data. The new molecules have been evaluated for their potential anti-inflammatory and analgesic activity. Compound TB1 and TB2 were found to possess anti-inflammatory.
Key words: Thiazolidinones, Anti-inflammatory activity.

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