Dipak T. Tayade1*, Sanghapal S. Padhen2
1Dept. of Chemistry, Govt. Vidarbha Institute of Science & Humanities, Amravati-444 604, (MS), India
2Dept. of Chemistry, Rajarshee Shahu Science College, Chandur Rly Dist Amravati-444904, (MS), India.
A B S T R A C T
Recently in this laboratory series of 1-phenyl-3-[4-(2-p-Cl-phenylimino-4-substituted imino-1,3,5-dithiazino)-amino phenyl]-prop-2-ene-1-ones (VIIIea-ee) had been synthesized by the interaction of 1-phenyl-3-[4-(5-p-Cl-phenyl-2,4-dithiobiureto) phenyl]-Prop-2-ene-1-ones (Ve) with various isocyanodichlorides(VIIa-e) in acetone medium. The reaction mixture was reflux 4 hours and filtered in hot condition. After distillation of excess of solvents crystals were separated out, this on basification with ammonium hydroxide gave product. The structures of all synthesized compounds were justified on the basis of chemical characteristics, elemental analysis and spectral studies.
Keywords: anti-HIV drugs, Heterocyclic, 1, 3, 5-dithiazines