Thursday , 15 November 2018

Synthesis and Anticonvulsant Activity of Some 1,4-Dihydropyridine Derivatives

Safia Begum*1, 2Dr. K. Sirisha
1Asst.Professor, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda.
2Associate Professor, Vaagdevi College of Pharmacy, Hanamkonda

 A B S T R A C T
A series of symmetrical and unsymmetrical 4-alkyl/aryl-2,6-dimethyl-3,5-bis-(ethoxycarbonyl)-1,4-dihydropyridines and 4-alkyl/aryl/-2,6-dimethyl-3-N-(aryl/heteroaryl)-carbamoyl-5-ethoxycarbonyl-1,4-dihydropyridine derivatives were prepared by the classical Hantzch method. This method involved condensation of various benzaldehydes, ethylacetoacetate, 2-aminopyridine or p-toludine in ethanol. The structures of all synthesized 1,4-dihydropyridine derivatives were confirmed by spectral data (IR, 1HNMR) and elemental analysis. Compounds IIIa-c and IVa-b (10 mg/kg) were evaluated for their anticonvulsant effect against pentylenetetrazole-induced convulsions with phenytoin (4 mg/kg) as the reference. The anticonvulsant potential of newly synthesized compounds were evaluated on the basis of increase in latency (onset time) to induce convulsions, decrease in number of convulsions and increase in latency of death compared to control and standard.
Keywords: 1,4-dihydropyridine, Hantzsch method, Pentylenetetrazole Method.

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