Friday , 28 April 2017

Subacute toxicity of Gallic acid, isolated form Terminalia chebula in Swiss Albino Mice

Sravan Kumar Reddy Theepireddy*1, Nagaraj M Kulkarni2, Ramakrishna Chinthala1Vaikunta Rao3, Pranesha Setty2, Rathanakar Reddy Kura2, MallikarjunaRao Duvvada1
1Department of Environmental Studies, GITAM Institute of Sciences, GITAM University, Visakhapatnam-530045. India

2Hetero Research Foundation. Plot No 80 and 81 A.P.I.E, Balanagar Hyderabad-500018. India
3Department of Chemistry, GITAM Institute of Sciences, GITAM University, Visakhapatnam-530045. India.

A B S T R A C T
Gallic acid (GA) is the major secondary metabolite observed in Terminaliachebula and is reported to possess various pharmacological activities. The present study was designed to evaluate the subacute toxicity of GA isolated from T. chebula using a standardized formulation with better pharmacokinetic profile in mice. Subacute treatment with formulation optimized GA at doses of 100, 300 and 1000 mg/kg for 14 days in Swiss albino mice did not produce any signs of toxicity or mortality. No significant effect was observed on body weight, feed intake, hematological parameters and histopathology at all the dose levels tested. In conclusion, GA is found to be non- toxic up to 1000 mg/kg body weight dose in Swiss albino mice up to 14 days. Further studies are being conducted in our laboratory to further understand the safety and efficacy of GA.

Keywords: Terminaliachebula, Gallic acid, Mice, Subacute toxicity

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