Wednesday , 23 August 2017

Study of Effect of Various-Natural Polymers in the Formulation Development of Mucoadhesive Buccal Tablets of Labetalol HCl

Y. Krishna Reddy*, G. Ganagaraju, G. Sravanthi, K. Srinivas Rao, K. Manisha, K. Mounika
Bomma Institute of Pharmacy, Khammam, Telangana, India

A B S T R A C T
Labetalol was formulated as buccal tablets to improve its bioavailability by avoiding first pass metabolism. HPMC K4M, HPMC K15M and HPMC K100M were selected as polymers and various formulations were prepared by using these polymers. The pre-compression blend of Labetalol buccal tablets were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio and all the results indicated that the blend was having good flow nature and better compression properties. The swelling studies were performed for the formulations which were shown desired drug release. The formulations prepared with HPMC K100M in the concentration of 20 mg (F7) was showing better result 98.23% drug release. The swelling studies were performed for the formulations which were shown desired drug release and the value was found to be 68.5 % in 12 hours. Ex-vivo residence time, Moisture absorption, surface pH, Bioadhesion strength values for selected formulations were found to be good.
Keywords: Labetalol, HPMC K4M, HPMC K15M, HPMC K100M, Buccal tablets.

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