S. Sivakumar1,*, R. Arulraj2, J. John Francis Xavier3, Hema Ramesh1, K. Mageswari1 , A. Rajappa1
1Department of Chemistry, Sri Manakula vinayagar Engineering College, Madagadipet, Pondicherry-605107, India.
2Department of Chemistry, Bharathiar University, Coimbatore-641046, India
3Department of Chemistry, Anna University campus, Panruti, India
A novel synthesis of t(3)-Methyl-r(2),c(6)-diarylpiperidin-4-onecyanoaceticacidhydrazones 1–3were synthesized and Characterized by IR, 1H and 13C NMR spectral studies. The structures were investigated for antibacterial and antifungal activity. the observed vicinal proton-proton coupling constants suggest that 1-3 adopts chair conformation with the equatorial orientations of all substituent’s.
Keywords: piperidin-4-onecyanoaceticacidhydrazone, Spectral, antibacterial, antifungal activity